I'm picturing a "how we are truly like animals" sort of drama. It doesn't have to be as harrowing as Lord of the Flies (one of the relatively few books I've started and didn't finish; I tried it about 10 years ago); maybe it's a story of a home that influences us to be closer in behavior to animals. A house that brings out your base side. And again, I'm not picturing much comic relief here, or a jaunty-pompous Elmer Bernstein score, or anyone dressed as a pirate: it's surprisingly easy to imagine snippets of a deadly serious story that just happens to be called Animal House.
Feel free to agree, debate, or violently disagree with me, or create your own alternate universe Animal House. You can call it House of the Animals if that gives you a better hook on which to throw your thoughts.